The 15th International p53 Workshop will be held October 8-12, 2010 in Philadelphia at the University of Pennsylvania School of Medicine.
Registration for the 15th International p53 Workshop will be open until September 1. Abstract submission is closed.We look forward to welcoming you to Philadelphia!
This Workshop, held every other year and now celebrating its 30th year, has consistently attracted the premier researchers in the fields of p53, cell death, oncology and drug discovery. The discoverers of the p53 tumor suppressor gene, Dr. Arnold Levine and Sir David Lane, will present keynote addresses. The talks that follow, presented by the leading researchers on p53, will address biology, drug discovery, protein modifications, cell death pathways and animal models of cancer.
The Workshops have consistently led to novel ideas for therapy, and open new directions in fundamental research for basic and applied scientists. More than 300 participants and presenters are expected to attend. As in previous years, we expect that new and important unpublished basic, translational and clinical research findings will be presented by the premier scientists in cancer biology.
p53 research has enormous clinical potential for cancer therapy. It is now believed that the p53 pathway is disabled in virtually all human cancers. Approximately half of all tumors express high levels of pro-oncogenic mutant p53. A high proportion of the remaining tumors have deregulated Mdm2 (the negative regulator of p53) and the rest have inactivated key upstream or downstream p53 regulators. Novel and exciting p53 therapeutics have been reported at this meeting, including compounds that inactivate Mdm2 or counteract mutant p53 along with novel gene therapeutic approaches. In concert, new epidemiological studies are pointing the way towards identifying populations and patient cohorts that can uniquely benefit from such therapeutics.
The 15th International p53 Workshop will be held on the beautiful campus of the University of Pennsylvania School of Medicine, with Keynote addresses at the majestic Irvine Auditorium (modeled after the Mont-Saint-Michel monastery in France), a poster session in the Upper Egyptian Gallery at the Penn Museum, an open-air Trolley Tour through Philadelphia's historic district (including the Liberty Bell and Independence Hall) and a final banquet at the National Constitution Center in Philadelphia.