Mesothelioma and Pleural Disease Treatment at Penn Medicine

When treating patients with mesothelioma or pleural disease, Penn Medicine pleural specialists offer more treatment options than most other health systems across the country and around the world.

Penn Medicine's Mesothelioma and Pleural Program and Penn's Abramson Cancer Center in Philadelphia, PA bring together internationally renowned experts in medical, surgical and radiation oncology and pulmonology who collaborate in the diagnosis, treatment and research of mesothelioma and pleural disease.

Focus on Mesothelioma

Mesothelioma is a rare type of cancer that affects the lining of the chest or abdominal cavities. It is most often attributed to exposure to airborne asbestos particles and occurs in both men and women. Asbestos fibers are naturally occurring fibrous minerals that were commonly used in construction and thermal insulation as a fire retardant until the 1970s. Asbestos is still used in products, but regulations in place since the 1980s limit its use.

Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.

Penn's multidisciplinary approach to cancer diagnosis and treatment provides better outcomes and gives patients access to the most advanced treatment, surgical techniques and clinical trials.

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Diagnosing Mesothelioma and Pleural Disease

An accurate diagnosis is the key to providing patients with the high level of care that they require for mesothelioma or pleural disease. At Penn, specialists who have extensive experience diagnosing and treating these complex conditions employ the latest tests and tools to provide patients with a timely, accurate diagnosis.

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Mesothelioma and Pleural Disease Treatment

Penn Medicine's pleural specialists develop personalized treatment plans for patients with mesothelioma and pleural disease, designed to give every patient the best possible outcome. Penn's treatment options for mesothelioma and pleural disease include:

  • Surgery
    • Extrapleural pneumonectomy
    • Indwelling pleural catheter (IPC)
    • Lung-sparing surgery
    • Minimally invasive surgery
    • Peritoneal cytoreductive surgery
    • Pleural sclerosis and fibrinolytics
    • Therapeutic thoracentesis
    • Thoracotomy
    • Video-assisted thoracoscopic surgery (VATS)
  • Radiation Therapy
    • Brachytherapy
    • Intensity-modulated radiation therapy (IMRT)
    • Photodynamic therapy (PDT)
    • Proton therapy
    • Volumetric-modulated arc therapy (VMAT)
  • Chemotherapy and Biologic Therapies
    • Combination chemotherapy
    • Immunotherapy
    • Targeted therapies
    • Gene therapy
    • Adjuvant therapy
  • Interventional Pulmonology Treatments
    • Endobronchial ultrasound-guided biopsy and mediastinal staging
    • Pleuroscopy and pleurodesis
  • Clinical Trials
  • Other Treatments
    • Integrative medicine and wellness
    • Palliative care
    • Penn Home Care and Hospice

Patients who come to Penn Medicine for their cancer care benefit from coordinated care across disciplines and modalities. The expertise of Penn's Abramson Cancer Center in cancer diagnosis, treatment planning and integrated medicine, helps patients who come to Penn Mesothelioma and Pleural Program receive nationally recognized care that leads to better outcomes and improved quality of life.

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Mesothelioma and Pleural Disease Survivorship

At Penn Medicine, significant research in the diagnosis and treatment of mesothelioma and pleural disease is giving patients with these conditions new hope for long-term survival.

To meet patients' varied physical, emotional and financial needs, Penn's robust network of navigation specialists includes social workers, stress management specialists, alternative medicine practitioners and clergy. Additionally, the support groups and survivorship programs at Penn provide patients and their families with a valuable network that serves to enhance and extend the quality of life following a cancer diagnosis.

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Edith Christmas

Edith Christmas lives up to the giving spirit of her last name. While caring for her ailing sister, Edith ignored the pain she was experiencing.

Abramson Cancer Center VideoWatch Focus on Lung Cancer Conference - Get information on the latest advances in lung cancer risk, prevention, diagnosis, treatment, symptom management and psychosocial issues.

Abramson Cancer Center VideoMedia Hub for Lung Cancer, Mesothelioma and Related Disorders - Watch Videos!

Abramson Cancer Center Video

Watch Focus on Mesothelioma Conference - Get information on the latest advances in mesothelioma risk, prevention, diagnosis, treatment, symptom management and psychosocial issues.

Clinical Trials

Mesothelioma Trials

A Phase 1 Study of the Safety, Tolerability, Pharmacokinetics and Immunoregulatory Activity of... more