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David Roth, MD, PhD

Abramson Cancer Center

Degree and Institution

1986, Baylor College of Medicine

Abramson Cancer Center Title

Chair, Department of Pathology and Laboratory Medicine

Department

Pathology and Laboratory Medicine

Research Expertise

Research Expertise (in a few sentences): My lab has focused on understanding the mechanism and regulation of V(D)J recombination and has been continuously funded by NIH since 1993. Since our discovery of RAG mutants that permit efficient alternative NHEJ (Nature, 2007), my lab has been generating and characterizing mice bearing knockin RAG mutants. We have found that RAG2 mutants which permit alternative NHEJ rapidly develop T lymphomas, with 100% penetrance, which contain chromosome translocations involving antigen receptor loci, interstitial deletions, and gene amplification, all features found in human T- acute lymphoblastic lymphoma (Deriano et al, Nature 2011). We continue to generate novel mouse models of lymphoma and are analyzing the genomic rearrangements of the lymphomas in an effort to understand mechanism and to discover oncogenic pathways.

Other Affiliations
Clinical Practices of the University of Pennsylvania; Diplomate, American Board of Pathology; Association of American Physicians; American Association of University Pathologists (The Pluto Society); American Association for the Advancement of Science; New York Academy of Sciences

Residency
1991, National Cancer Institute

Fellowship
1993, National Institute of Diabetes & Digestive & Kidney Diseases

Board Certifications
1992, American Board of Pathology (Anatomic Pathology)

Honors and Award

2009: Teacher of the Year Award, Medical School Class of 2009, NYU School of Medicine
2008: Distinguished Teacher, Basic Sciences, New York University School of Medicine
2005: Teacher of the Year, First Year Medical Students, New York University School of Medicine
1999: Teaching Excellence Award, Graduate Students, Baylor College of Medicine
1998: Innovative Teaching Award, American Medical Association
1995-1998: Charles E. Culpeper Medical Scholar
1988: Alpha Omega Alpha Medical Honor Society

Publications

Click here to see my publications

In the News In the News

Contact Information

Researcher/Clinician:
David Roth

6.036 Gates Building
3400 Spruce Street
Philadelphia, PA 19104-4283

Office Phone: 215-615-6510
Fax: 215-662-4063

Assistant:
Zoe Zampana
Office Phone: 215-615-6510
Appointment Phone: 215-615-6510
Fax: 215-662-4063
zampanaz@upenn.edu