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Andrei Thomas-Tikhonenko, PhD

Abramson Cancer Center

Degree and Institution

Russian Academy of Medical Sciences, Moscow

Faculty Title

Professor of Pathology & Laboratory Medicine

Administrative Title

Chief, Division of Cancer Pathobiology (CHOP)

Research Expertise

My lab studies neoplastic transformation by the Myc family oncoproteins. To this end, we developed a mouse model for B-cell lymphoma based on infection of p53-null bone marrow progenitors by a Myc-encoding retrovirus (Yu et al, Blood 2007; Cozma et al, J Clin Invest 2007). In this system, the salient features of Myc-induced lymphomagenesis are overexpression of the oncogenic miR-17-92 microRNA cluster and repression of several tumor suppressive microRNAs, such as miR-15/16, miR-34, and let-7 (Chang et al, Nature Genet 2008; Chang et al, Proc Natl Acad Sci 2009). These microRNAs help sustain c-Myc levels and contribute to deregulation of multiple Myc target genes, B-cell receptor signaling, and therapeutic apoptosis (Sotillo-Pineiro et al, Oncogene 2011; Chung et al, J Clin Invest 2012, Psathas et al, Blood 2013). In solid tumors, deregulation of miR-17-92 leads to profound suppression of TGFbeta signaling and sharply diminished production of many anti-angiogenic factors such as thrombospondin-1 (Dews et al, Nature Genet 2006; Chayka et al, J Natl Cancer Inst 2009; Dews et al, J Natl Cancer Inst 2014). This brings about robust tumor neovascularization and enhanced neoplastic growth, but also enables new therapeutic strategies based on inhibition of the Myc-miR axis.

Other Affiliations
The Children's Hospital of Philadelphia

Fellowship
Fred Hutchinson Cancer Research Center

Honors and Award

  • 2014-2015 The Leukemia & Lymphoma Society Quest for Cures Award Recepitent
  • 2013-2017 Immunogenomics Pediatric Dream Team Investigator, Stand Up To Cancer - St. Baldrick's Foundation
  • 2013 Ethel Brown Foerderer Fund for Excellence Award
  • 2012 Department of Cancer Biology 4th Annual Award for Excellence in Teaching, Perelman School of Medicine at the University of Pennsylvania
  • 2011-present Mildred L. Roeckle Endowed Chair in Pathology at The Children's Hospital of Philadelphia
  • 2010-2013 Innovation Award, Alex's Lemonade Stand Foundation
  • 2005    Pfizer Award for Research Excellence, Pfizer Animal Health
  • 1999-2005 Elizabeth & William Whitney Clark Developmental Chair in Oncology, University of Pennsylvania
  • 1997-2002 NIH FIRST Award
  • 1994-1997 Special Fellow, Leukemia Society of America
  • 1990 ICRETT Award (short-term exchange), International Union Against Cancer

Publications

Click here to see my publications

Contact Information

Researcher/Clinician:
Andrei Thomas-Tikhonenko

4056 Colket Translational Research Bldg
3501 Civic Center Blvd
Philadelphia, PA 19104-4399

Office Phone: 267-426-9699
Fax: 267-426-8125
andreit@mail.med.upenn.edu

Assistant:
Kate Wurges
Office Phone: 267-426-8150
Appointment Phone: 267-426-8150
Fax: 267-426-2791
wurgesk@email.chop.edu